does anyone know...

In the Shivering isle city, if you kill the daedra guards of the city are they infinitelly replaced like i beleive they are in the main game?

and is it possible to kill the Daerdra lord without working for him first (i dont need to know how just a yes or no would be cool)
THanks people

Sheogorath cannot be killed. If you strike him, he casts a touch spell on you which sends you falling from thousands of feet and dying near a ruin near New Sheoth. Running away doesn't help, it still has effect. Not even someone using mods and having 225 acrobatics and agility could survive this.
The Daedric Guards (Golden Saints and Dark Seducers) can die, and once they do, a new guard is posted in position but the guard doesn't resurrect. This happens in the Imperial City, I killed Legion Guard at his gate post and another one, identicle, returned a few days later, wasn't him though because the corpse was still there.